Bioprospecting for seaweed-derived multimodal acting products have earned increasing attention in the fight against diseases of multifactorial origin, such as neurodegenerative conditions. This is a pioneer study on the in vitro screening of neuroactive properties of phlorotannin-targeted extracts from edible Fucus species. Phlorotannin extracts exhibited multifunctional antioxidant properties, which were suggested to be responsible for counteracting glutamate toxicity in neuronal human-derived SH-SY5Y cells. They also inhibited the activity of enzymes (cholinesterases, monoaminoxidases A and B, and tyrosinase) linked to a set of events that contribute to the onset/progression of neurodegeneration. In general, the bioactivities were correlated with the total phlorotannin content and phloroglucinol tetramers were suggested to be behind the observed effects. The capacity of the phlorotannin extracts to interact with multiple in vitro targets underpinning neurodegeneration points to the potential interest of the selected seaweed species for development of new added-value products and promising neuroactive agents.

海藻衍生的多峰作用产物的生物勘探在对抗多因素起源的疾病（例如神经退行性疾病）中已受到越来越多的关注。这是对的先驱研究体外筛选，从食用phlorotannin针对性提取的神经刺激性质的墨角藻种类。伞菌素提取物表现出多功能的抗氧化性能，这被认为可以抵消神经元人源性SH-SY5Y细胞中的谷氨酸毒性。它们还抑制了与一系列事件相关的酶（胆碱酯酶，单氨基氧化酶A和B和酪氨酸酶）的活性，这些事件有助于神经变性的发生/发展。通常，生物活性与总的邻苯二酚单宁含量有关，建议的间苯三酚四聚体落后于所观察到的效果。Phrotrotannin提取物与支持神经变性的多个体外靶标相互作用的能力表明，所选海藻物种对开发新的增值产品和有前途的神经活性剂的潜在兴趣。