The existing information supports the use of this material as described in this safety assessment. Decanoic acid was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data on the target material and from read-across analog nonanoic acid (CAS # 112-05-0) show that decanoic acid is not expected to be genotoxic. Data on read-across analog octanoic acid (CAS # 124-07-2) provide a calculated MOE >100 for the repeated dose and reproductive toxicity endpoints. Based on the existing data, decanoic acid does not present a concern for skin sensitization under the current, declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; decanoic acid is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material, and the exposure to decanoic acid is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; decanoic acid was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.

现有信息支持本安全评估中所述材料的使用。评估癸酸的遗传毒性，重复剂量毒性，生殖毒性，局部呼吸毒性，光毒性/光致敏性，皮肤致敏性和环境安全性。目标物质的数据和交叉阅读的类似壬酸（CAS＃112-05-0）的数据表明，癸酸不具有遗传毒性。跨模拟辛酸（CAS＃124-07-2）的数据提供了重复剂量和生殖毒性终点的计算出的MOE> 100。根据现有数据，癸酸在当前已宣布的使用水平下不会引起皮肤过敏。基于UV光谱评估了光毒性/光致敏性终点。癸酸预计不会具有光毒性/光致敏性。对于Cramer I类材料，使用TTC评估了局部呼吸毒性终点，并且癸酸的暴露低于TTC（1.4 mg /天）。评估了环境指标；根据IFRA环境标准，发现癸酸不是PBT，根据其在欧洲和北美当前的使用量（即PEC / PNEC），其癸酸商<1。