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Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.
Food and Chemical Toxicology ( IF 4.3 ) Pub Date : 2020-07-05 , DOI: 10.1016/j.fct.2020.111558
Denisa Margină 1 , Anca Ungurianu 1 , Carmen Purdel 2 , George Mihai Nițulescu 3 , Dimitris Tsoukalas 4 , Evangelia Sarandi 5 , Maria Thanasoula 6 , Tatyana I Burykina 7 , Fotis Tekos 8 , Aleksandra Buha 9 , Dragana Nikitovic 10 , Demetrios Kouretas 8 , Aristidis Michael Tsatsakis 11
Affiliation  

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments – redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. In the present manuscript we have reviewed scientific data from recent publications regarding the beneficial cellular and molecular effects induced by dietary plant products, mainly polyphenolic compounds and PUFAs, and summarize the clinical outcomes expected from these types of interventions, in a search for effective long-term approaches to improve the immune system response.



中文翻译:

分析多不饱和脂肪酸和多酚对健康和疾病炎症通路的复杂影响。

预防和治疗非传染性疾病(NCDs),包括心血管疾病、糖尿病、肥胖症、癌症、老年痴呆症和帕金森病、关节炎、非酒精性脂肪肝和各种传染病;最近最著名的是 COVID-19 一直处于全球研究的前沿。虽然针对不同的器官,但这些病理学具有共同的生化损伤——氧化还原差异,以及最显着的炎症通路失调。研究数据表明,多酚、多不饱和脂肪酸 (PUFA)、纤维以及生活方式(禁食、体育锻炼)等饮食成分是影响信号通路的重要因素,具有改善代谢稳态和免疫细胞功能的巨大潜力。

更新日期:2020-07-08
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