Anemia is an inherent complication of older individuals with end-stage renal disease (ESRD) that is associated with inflammation which in turn is an important factor in the activation of hepcidin that contributes to the decrease in serum iron. Athough resistance training (RT) seems to reduce inflammation in ESRD, its influence on hepcidin and iron availability in hemodialysis patients is unclear. Therefore, the aim of this study was to exemine the effects of RT in on inflammatory profile, hepcidin, and iron status in older individuals with ESRD. End-stage renal disease patients (N: 157, age: 66.8 ± 3.6; body mass: 73 ± 15 body mass index:27 ± 3), were assigned to control (CTL n: 76) and exercise groups (RT n: 81). RT consisted of 24 weeks/3 days per week of a moderate intensity. There was an increase in the bioavailability of iron (ΔRT: 22.2; ΔCTL: −1 μg/dL, p < 0.0001), a decrease in hepcidin levels (ΔRT: -7.9; ΔCTL: 0.2 ng/mL, p < 0.0001),and an improvement of the inflammatory profile. These novel findings show that RT is a potential coadjuvant to reduce iron deficiency by decreasing the levels of hepcidin and pro-inflammatory markers in older patients undergoing hemodialysis.

贫血是患有终末期肾病 (ESRD) 的老年人的固有并发症，与炎症有关，而炎症又是铁调素激活的重要因素，导致血清铁的降低。尽管阻力训练 (RT) 似乎可以减少 ESRD 的炎症，但其对血液透析患者铁调素和铁可用性的影响尚不清楚。因此，本研究的目的是探讨 RT 对 ESRD 老年患者炎症特征、铁调素和铁状态的影响。终末期肾病患者（N：157，年龄：66.8 ± 3.6；体重：73 ± 15 体重指数：27 ± 3）被分配到对照组（CTL n：76）和运动组（RT n：81 ）。RT 包括每周 24 周/3 天的中等强度。铁的生物利用度增加（ΔRT：22.2；ΔCTL：p  < 0.0001），铁调素水平降低（ΔRT：-7.9；ΔCTL：0.2 ng/mL，p  < 0.0001），以及炎症特征的改善。这些新发现表明，RT 是一种潜在的辅助辅助手段，可通过降低接受血液透析的老年患者的铁调素和促炎标志物水平来减少铁缺乏症。