Aging accelerates neurodegeneration, while natural and safe neuroprotective agents, such as Uncaria tomentosa, may help to overcome this problem. This study assessed the effects of U. tomentosa extract treatment on the aging process in the brain of Wistar rats. The spatial memory and learning, acetylcholinesterase (AChE) activity, and DNA damage were assessed. Animals of 14 months were tested with different doses of U. tomentosa (5 mg/kg, 15 mg/kg, and 30 mg/kg) and with different durations of treatment (one month and one year). In the Morris Water Maze (MWM), the escape latency was significantly (p < 0.0001) shorter in rats that received 5 mg/kg, 15 mg/kg, and 30 mg/kg of U. tomentosa for both one month and one year of treatment. There was a significant difference in time spent at the platform zone (p < 0.05) of the middle-aged rats treated with U. tomentosa extract for one year when compared to the control rats. The cortex and hippocampus of rats treated with U. tomentosa for one year showed significant (p > 0.05) reduction in AChE activity. DNA damage index on cortex was significantly lower (p < 0.05) in animals treated with 30 mg/kg of U. tomentosa for one month while all the tested doses demonstrated significant (p < 0.001) reductions in DNA damage index in animals treated for one year. In conclusion, U. tomentosa may represent a source of phytochemicals that could enhance memory activity, repair DNA damage, and alter AChE activity, thereby providing neuroprotection during the aging process.

衰老会加速神经退行性变，而天然安全的神经保护剂（如毛白Uncaria）可能有助于克服这一问题。这项研究评估了毛绒球菌提取物处理对Wistar大鼠大脑衰老过程的影响。评估了空间记忆和学习，乙酰胆碱酯酶（AChE）活性和DNA损伤。对14个月的动物进行了不同剂量的毛白粉虱（5 mg / kg，15 mg / kg和30 mg / kg）和不同的治疗时间（一个月和一年）的测试。在莫里斯水迷宫（MWM）中，在 接受5 mg / kg，15 mg / kg和30 mg / kg毛绒球菌的大鼠中，逃避潜伏期明显缩短（p <0.0001）。治疗一个月和一年。与对照大鼠相比， 用绒毛衣原体提取物治疗一年的中年大鼠在平台区花费的时间有显着差异（p <0.05）。毛绒球菌治疗一年的大鼠皮质和海马显示出 AChE活性显着降低（p > 0.05）。 在用30 mg / kg毛绒球菌治疗1个月的动物中，皮层上的DNA损伤指数显着降低（p <0.05），而所有测试剂量均表明，用1 mg毛绒绒球菌 治疗的动物中DNA损伤指数显着降低（p <0.001）。年。最后，毛白杨 可能代表一种植物化学物质的来源，可以增强记忆活性，修复DNA损伤并改变AChE活性，从而在衰老过程中提供神经保护作用。