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Cd exposure-induced growth retardation involves in energy metabolism disorder of midgut tissues in the gypsy moth larvae.
Environmental Pollution ( IF 8.9 ) Pub Date : 2020-07-05 , DOI: 10.1016/j.envpol.2020.115173
Dun Jiang 1 , Yantao Zhou 2 , Mingtao Tan 1 , Jie Zhang 1 , Qingxi Guo 3 , Shanchun Yan 1
Affiliation  

Cadmium, a common environmental contaminant in both terrestrial and aquatic ecosystems, presented a serious hazard to growth and development of phytophagous insects. For better understanding the toxicology of Cd exposure on phytophagous insects, the physiological and molecular mechanisms underlying the energy metabolism disorder in midgut tissue of gypsy moth larvae fed on Cd-amended artificial diets (3.248 or 44.473 mg Cd/kg fresh food) were investigated. Our results showed that compared with control, Cd exposure at both two levels triggered detriment effects on growth indexes, and with the increase of exposure concentrations, the adverse effects were significantly exacerbated. Larval growth and nutritional indexes (except approximate digestibility) showed a strong positive correlation, indicating that growth retardation in the gypsy moth larvae under Cd stress was tightly related to the food utilization. The key genes at mRNA level in glycolysis/gluconeogenesis, citrate cycle pathway and starch/sucrose metabolism pathway also presented a significant and positive correlation with growth indexes, once again demonstrating that energy metabolism was the key factor that controls the growth and development of the gypsy moth larvae under Cd stress. Antioxidant system collapse and oxidative damage, a chief cause of histopathological alterations in midgut tissue, consist of the physiological basis of energy metabolism disorder in Cd-treated gypsy moth larvae. Together, these results suggest that histopathological alterations or oxidative damage of tissue structure significant disturbed physiological functions of midgut tissue in gypsy moth larvae exposed to Cd stress, as reflected via food utilization or energy metabolism disorder, and eventually resulted in larval growth retardation.



中文翻译:

镉暴露引起的生长迟缓涉及吉卜赛蛾幼虫中肠组织的能量代谢紊乱。

镉是陆生和水生生态系统中常见的环境污染物,对植食性昆虫的生长和发育构成了严重危害。为了更好地了解Cd暴露于食植物昆虫上的毒理学,研究了使用改良的Cd人工饮食(3.248或44.473 mg Cd / kg新鲜食物)喂养的吉卜赛蛾幼虫中肠组织能量代谢紊乱的生理和分子机制。我们的结果表明,与对照相比,两个水平的Cd暴露都对生长指数产生不利影响,并且随着暴露浓度的增加,其不良影响显着加剧。幼虫的生长和营养指标(近似消化率除外)显示出很强的正相关关系,表明镉胁迫下吉卜赛蛾幼虫的生长迟缓与食物利用密切相关。糖酵解/糖异生,柠檬酸循环途径和淀粉/蔗糖代谢途径中mRNA水平的关键基因也与生长指标呈显着正相关,再次证明能量代谢是控制吉卜赛人生长发育的关键因素。镉胁迫下的蛾类幼虫。抗氧化系统的崩溃和氧化损伤是中肠组织组织病理学改变的主要原因,由镉处理的吉卜赛蛾幼虫能量代谢紊乱的生理基础组成。一起,

更新日期:2020-07-13
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