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Triazole resistance in Aspergillus fumigatus in crop plant soil after tebuconazole applications.
Environmental Pollution ( IF 8.9 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.envpol.2020.115124
Duantao Cao 1 , Ruilin Wu 1 , Suxia Dong 1 , Feiyan Wang 1 , Chao Ju 1 , Sumei Yu 1 , Shiji Xu 1 , Hua Fang 1 , Yunlong Yu 1
Affiliation  

Aspergillus fumigatus is the primary agent of invasive aspergillosis (IA) causing high morbidity and mortality in immunocompromised patients. Triazole resistance in A. fumigatus and its sources have gained wide attention. For several years, environmental fungicides use has been proposed as the major cause for triazole resistance in A. fumigatus. However, there are few studies on azole-resistant A. fumigatus (ARAF) selected by triazole fungicides in agricultural systems. We studied the possible emergence of ARAF in the field after exposure to triazole fungicide tebuconazole. Our results showed that exposure to tebuconazole in soil selects for resistance to triazoles in A. fumigatus. The probability of ARAF developing in soils depends upon the concentrations of tebuconazole after application. We suggest that tebuconazole applications should be minimized to reduce selective pressure for the generation of ARAFs.



中文翻译:

戊唑醇施用后作物土壤中烟曲霉对三唑的抗性。

烟曲霉是侵入性曲霉病(IA)的主要药物,在免疫功能低下的患者中会引起较高的发病率和死亡率。烟曲霉及其来源中对三唑的耐药性已引起广泛关注。几年来,已提出使用环境杀真菌剂作为烟曲霉中三唑抗性的主要原因。但是,在农业系统中,关于由三唑类杀菌剂选择的对唑类具有抗性的烟曲霉(ARAF)的研究很少。我们研究了三唑类杀菌剂戊唑醇在田间出现ARAF的可能性。我们的结果表明,暴露于土壤中的戊唑醇会使烟曲霉对三唑类药物产生抗性。ARAF在土壤中生长的可能性取决于施用后戊唑醇的浓度。我们建议应尽量减少戊唑醇的使用,以降低产生ARAF的选择性压力。

更新日期:2020-07-05
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