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Recent advances in single-molecule fluorescence microscopy render structural biology dynamic.
Current Opinion in Structural Biology ( IF 6.8 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.sbi.2020.05.006 Luka Bacic 1 , Anton Sabantsev 1 , Sebastian Deindl 1
中文翻译:
单分子荧光显微镜的最新进展使结构生物学充满活力。
更新日期:2020-07-05
Current Opinion in Structural Biology ( IF 6.8 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.sbi.2020.05.006 Luka Bacic 1 , Anton Sabantsev 1 , Sebastian Deindl 1
Affiliation
Single-molecule fluorescence microscopy has long been appreciated as a powerful tool to study the structural dynamics that enable biological function of macromolecules. Recent years have witnessed the development of more complex single-molecule fluorescence techniques as well as powerful combinations with structural approaches to obtain mechanistic insights into the workings of various molecular machines and protein complexes. In this review, we highlight these developments that together bring us one step closer to a dynamic understanding of biological processes in atomic details.
中文翻译:
单分子荧光显微镜的最新进展使结构生物学充满活力。
长期以来,单分子荧光显微镜一直被认为是研究实现大分子生物功能的结构动力学的有力工具。近年来见证了更复杂的单分子荧光技术的发展以及与结构方法的强大组合,以获得对各种分子机器和蛋白质复合物工作的机械洞察力。在这篇评论中,我们强调了这些发展,它们共同使我们更接近于对原子细节中的生物过程的动态理解。