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Role of Probiotics in Oral Health Maintenance Among Patients Undergoing Fixed Orthodontic Therapy: a Systematic Review of Randomized Controlled Clinical Trials.
Probiotics and Antimicrobial Proteins ( IF 4.9 ) Pub Date : 2020-07-04 , DOI: 10.1007/s12602-020-09683-2
Francesca Katherine Pietri 1 , P Emile Rossouw 1 , Fawad Javed 1 , Dimitrios Michelogiannakis 1
Affiliation  

The aim was to assess the role of probiotics in oral health maintenance among patients undergoing fixed orthodontic therapy (OT). An unrestricted search of indexed databases was performed until April 2020 using the following Mesh-terms: (1) probiotic and (2) orthodontic. Randomized controlled clinical trials (RCTs) evaluating the influence of probiotic therapy (PT) towards oral health maintenance/improvement in patients undergoing fixed OT were included. Data screening, selection, and extraction were performed; and the risk of bias was assessed using the Cochrane Collaboration’s tool. All evaluations were performed by 2 independent researchers; and disagreements were resolved via discussion. Nine RCTs were included. Eight studies reported that PT improves oral health in patients undergoing fixed OT. Seven studies showed that PT reduces the counts of oral pathogenic bacteria in the oral biofilm and/or saliva. One study reported that PT reduces halitosis in patients undergoing fixed OT. One study found that PT reduces the scores of plaque index (PI) and gingival index (GI); and one study reported that PT has no significant influence on PI and GI in patients undergoing fixed OT. One study reported that PT does not prevent the formation of white spot lesions during fixed OT. Three and 6 studies had a moderate and low risk of bias, respectively. A power analysis was performed in 4 studies. In conclusion, probiotics exhibit antimicrobial activity against oral pathogenic bacteria; however, due to the limitations of the studies assessed, further well-designed RCTs are needed.



中文翻译:

益生菌在正畸固定治疗患者口腔健康中的作用:随机对照临床试验的系统评价。

目的是评估益生菌在接受固定正畸治疗(OT)的患者的口腔健康维持中的作用。截至2020年4月,使用以下网格术语对索引数据库进行了无限制搜索:(1)益生菌和(2)正畸。随机临床试验(RCT)评估了益生菌治疗(PT)对接受固定OT的患者口腔健康/改善状况的影响。进行数据筛选,选择和提取;并使用Cochrane协作工具评估了偏见的风险。所有评估均由2位独立研究人员进行;通过讨论解决了分歧。包括9个RCT。八项研究报告说,PT可改善接受固定OT的患者的口腔健康。七项研究表明,PT可以减少口腔生物膜和/或唾液中口腔致病细菌的数量。一项研究报告说,PT可减少接受固定OT的患者的口臭。一项研究发现PT可以降低斑块指数(PI)和牙龈指数(GI)的得分;一项研究报道,PT对固定性OT患者的PI和GI无明显影响。一项研究报道,PT不能预防固定OT期间白斑病变的形成。三项和六项研究的偏倚风险分别为中度和低度。在4个研究中进行了功效分析。总之,益生菌对口腔致病菌具有抗菌活性。但是,由于所评估研究的局限性,需要进一步设计良好的RCT。一项研究报告说,PT可减少接受固定OT的患者的口臭。一项研究发现PT可以降低斑块指数(PI)和牙龈指数(GI)的得分;一项研究报道,PT对接受固定OT的患者的PI和GI无明显影响。一项研究报道,PT不能预防固定OT期间白斑病变的形成。三项和六项研究的偏倚风险分别为中度和低度。在4个研究中进行了功效分析。总之,益生菌对口腔致病菌具有抗菌活性。但是,由于所评估研究的局限性,需要进一步设计良好的RCT。一项研究报告说,PT可减少接受固定OT的患者的口臭。一项研究发现PT可以降低斑块指数(PI)和牙龈指数(GI)的得分;一项研究报道,PT对接受固定OT的患者的PI和GI无明显影响。一项研究报道,PT不能预防固定OT期间白斑病变的形成。三项和六项研究的偏倚风险分别为中度和低度。在4个研究中进行了功效分析。总之,益生菌对口腔致病菌具有抗菌活性。但是,由于所评估研究的局限性,需要进一步设计良好的RCT。一项研究报道,PT对接受固定OT的患者的PI和GI无明显影响。一项研究报道,PT不能预防固定OT期间白斑病变的形成。三项和六项研究的偏倚风险分别为中度和低度。在4个研究中进行了功效分析。总之,益生菌对口腔致病菌具有抗菌活性。但是,由于所评估研究的局限性,需要进一步设计良好的RCT。一项研究报道,PT对接受固定OT的患者的PI和GI无明显影响。一项研究报告说,PT不能预防固定OT期间白斑病变的形成。三项和六项研究的偏倚风险分别为中度和低度。在4个研究中进行了功效分析。总之,益生菌对口腔致病菌具有抗菌活性。但是,由于所评估研究的局限性,需要进一步设计良好的RCT。益生菌对口腔致病菌具有抗菌活性;但是,由于所评估研究的局限性,需要进一步设计良好的RCT。益生菌对口腔致病菌具有抗菌活性;但是,由于所评估研究的局限性,需要进一步设计良好的RCT。

更新日期:2020-07-05
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