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Association of genetic polymorphism of BCL-2 (rs2279115) with susceptibility to HCV-related hepatocellular carcinoma.
Immunologic Research ( IF 4.4 ) Pub Date : 2020-07-04 , DOI: 10.1007/s12026-020-09143-7
Hanan S Ahmed 1 , Essam A Wahab 2 , Hoda A Elhady 2 , Manal M Elgerby 1
Affiliation  

Hepatitis C virus (HCV) infection is the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). B cell lymphoma-2 (BCL-2) prevents apoptosis, and its overexpression could promote cancer cell survival. The purpose of this study is to evaluate the association of Bcl-2 gene polymorphism (rs2279115) and HCV-related HCC susceptibility. Two hundred and seventy individuals included in this case-control were divided into three groups. Group I: It included 90 apparently healthy subjects as control. Group II: It includes 90 patients with chronic HCV hepatitis. Group III: It includes 90 patients with HCC with positive HCV. Bcl-2 gene polymorphism (rs2279115) C > A genotypes by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). There are significantly higher incidence of CA and AA genotypes in HCV patients with HCC compared with those without HCC (OR 2.3, %CI (1.2–4.6), P = 0.01 and OR 5.7, %CI (2.4–13.8), respectively) and compared with control group (OR 2.9, %CI (1.5–5.8), P = 0.002 and OR 7.1, %CI (2.9–17.4), P < 0.001, respectively), while no significant difference between the control and HCV patients without HCC groups (OR 1.2, %CI (0. 7–2.4), P = 0.48, for CA, and OR 1.2, %CI (0.4–3.3), P = 0.67, for AA).The frequency of A allele was highly significantly overrepresented in the HCC group in comparison to HCV group (53.3% versus 30.6%, P < 0.001) and control group (53.3% versus 27.2%, P < 0.001) but no significant difference (p = 0.49) between control group and HCV patients. This study demonstrated that Bcl-2 gene polymorphism (rs2279115) was associated with increased susceptibility to HCV-related HCC.



中文翻译:

BCL-2 (rs2279115) 基因多态性与 HCV 相关肝细胞癌易感性的关联。

丙型肝炎病毒 (HCV) 感染是慢性肝炎 (CHC)、肝硬化和肝细胞癌 (HCC) 的主要危险因素。B 细胞淋巴瘤-2 (BCL-2) 可防止细胞凋亡,其过表达可促进癌细胞存活。本研究的目的是评估 Bcl-2 基因多态性 (rs2279115) 与 HCV 相关 HCC 易感性的关联。该病例对照中包括的 270 个人被分为三组。第 I 组:包括 90 名明显健康的受试者作为对照。第二组:包括90名慢性丙型肝炎患者。第三组:包括 90 名 HCV 阳性的 HCC 患者。Bcl-2 基因多态性 (rs2279115) C > A 基因型通过聚合酶链反应限制性片段长度多态性 (PCR-RFLP)。分别为 P  = 0.01 和 OR 5.7, %CI (2.4–13.8)) 并与对照组比较 (OR 2.9, %CI (1.5–5.8), P  = 0.002 和 OR 7.1, %CI (2.9–17.4), P  < 0.001),而对照组和无 HCC 组的 HCV 患者之间没有显着差异(OR 1.2,%CI (0. 7-2.4),P  = 0.48,对于 CA,OR 1.2,%CI (0.4-3.3) ), 对于 AA ,P = 0.67。与 HCV 组(53.3% 对 30.6%,P  < 0.001)和对照组(53.3% 对 27.2%,P)相比,HCC 组中 A 等位基因的频率明显过高 < 0.001) 但无显着差异 ( p = 0.49) 在对照组和 HCV 患者之间。该研究表明 Bcl-2 基因多态性 (rs2279115) 与 HCV 相关 HCC 的易感性增加有关。

更新日期:2020-07-05
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