Background

Bone is one of the most common sites for solid tumor metastasis. Bone metastasis of a malignant tumor seriously affects the quality of life and the overall survival of patients. Evidence has suggested that bone provides a favorable microenvironment that enables disseminated tumor cells to home, proliferate and colonize, leading to the formation of metastases. In the process of bone metastasis the bone microenvironment may be considered as an orchestra that plays a dissonant melody through blending (e.g. cross-talk between osteoclasts, osteoblasts and/or other cells), adding (e.g. a variety of biological factors) or taking away (e.g. blocking a specific pathway) players.

Conclusions

Here, we review the normal bone microenvironment, bone microenvironment-related factors that promote bone metastasis, as well as mechanisms underlying bone metastasis. In addition, we elude on directions for clinical bone metastasis management, focusing on potential therapeutic approaches to target bone microenvironment-related factors, including bisphosphonate, denosumab, CXCR4/CXCL12 antagonists and cathepsin K inhibitors.

中文翻译：

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骨微环境在恶性肿瘤骨转移中的作用-治疗意义。

背景

骨是实体瘤转移的最常见部位之一。恶性肿瘤的骨转移严重影响患者的生活质量和整体生存。有证据表明，骨骼提供了有利的微环境，使已扩散的肿瘤细胞能够归巢，增殖和定居，从而导致转移的形成。在骨转移的过程中，骨微环境可被视为通过融合（例如破骨细胞，成骨细胞和/或其他细胞之间的串扰），添加（例如多种生物学因素）或起带走不和谐旋律的乐团（例如封锁特定路径）玩家。

结论

在这里，我们回顾了正常的骨骼微环境，与骨骼微环境相关的促进骨骼转移的因素以及骨骼转移的潜在机制。此外，我们还没有针对临床骨转移管理的方向，着眼于针对靶骨微环境相关因素的潜在治疗方法，包括双膦酸盐，地诺单抗，CXCR4 / CXCL12拮抗剂和组织蛋白酶K抑制剂。