In recent years, the features of lymphomas associated with chronic inflammation, referred to as diffuse large B-cell lymphoma (DLBCL) associated with chronic inflammation (DLBCL-CI), have been elucidated. DLBCL-CI is an aggressive lymphoma occurring in the context of long-standing chronic inflammation and showing an association with Epstein–Barr virus. Fibrin-associated diffuse large B-cell lymphoma (F-DLBCL) was suggested as a new and unusual form of DLBCL-CI in the most recent version of the World Health Organization classification. From the perspective of genetics, DLBCL-CI was associated with frequent TP53 mutation, MYC amplification and complex karyotypes, but cases of F-DLBCL behaved indolently and showed a relatively lower genetic complexity. In the central nervous system (CNS), several examples of DLBCL-CI and F-DLBCL have been reported. As with DLBCL-CI outside the CNS, DLBCL-CI in the CNS is an aggressive lymphoma. However, the clinical outcome of F-DLBCL in the CNS is good. Immunohistochemistry for p53 and c-Myc in DLBCL-CI and F-DLBCL in the CNS showed similar findings of those outside the CNS. However, one aggressive case showed transitional genetics and morphology between F-DLBCL and DLBCL-CI. These findings suggest that some cases of F-DLBCL in the CNS might have the potential to progress to DLBCL-CI.

近年来，已经阐明了与慢性炎症有关的淋巴瘤的特征，称为与慢性炎症有关的弥漫性大B细胞淋巴瘤（DLBCL-CI）。DLBCL-CI是一种侵袭性淋巴瘤，发生于长期慢性炎症的背景下，显示与爱泼斯坦-巴尔病毒相关。在世界卫生组织分类的最新版本中，纤维蛋白相关性弥漫性大B细胞淋巴瘤（F-DLBCL）被认为是DLBCL-CI的一种新的且不寻常的形式。从遗传学的角度来看，DLBCL-CI与频繁的TP53突变，MYC有关扩增和复杂的核型，但F-DLBCL病例表现不佳，遗传相对较低。在中枢神经系统（CNS）中，已经报道了DLBCL-CI和F-DLBCL的几个例子。与中枢神经系统外的DLBCL-CI一样，中枢神经系统中的DLBCL-CI是侵袭性淋巴瘤。但是，F-DLBCL在中枢神经系统的临床预后良好。中枢神经系统DLBCL-CI和F-DLBCL中p53和c-Myc的免疫组织化学显示与中枢神经系统以外的类似。然而，一个侵略性病例显示F-DLBCL和DLBCL-CI之间的过渡遗传学和形态。这些发现表明，CNS中某些F-DLBCL病例可能具有发展为DLBCL-CI的潜力。