Periurethral human mesenchymal stem cell (hMSC) injections are associated with functional improvement in animal models of postpartum stress urinary incontinence (SUI). However, limited data exist on the role of hMSCs in modulating gene expression in tissue repair after urethral injury. To this end, we quantified temporal gene expression modulation in hMSCs, and in injured rat urethral tissue, using RNA-seq in an animal model of SUI, over a 3-day period following urethral injury, and local hMSC injection.

中文翻译：

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人间充质干细胞治疗失禁大鼠尿道口的转录组学分析。

围尿道人间充质干细胞（hMSC）注射与产后应激性尿失禁（SUI）动物模型的功能改善有关。然而，关于hMSC在调节尿道损伤后组织修复中的基因表达中的作用的数据有限。为此，我们在尿道损伤和局部hMSC注射后的三天内，在SUI动物模型中使用RNA-seq定量了hMSCs和受损大鼠尿道组织中的时间基因表达调控。