We demonstrated the effect of a mixture containing fermented Achyranthes japonica Nakai (FS) in the context of a monosodium iodoacetate (MIA)-induced osteoarthritis animal model. The mineralization, anabolic and catabolic factors, and the amount of cytokines within the articular cartilage of rats were measured after administration of MIA. We found that dietary supplementation with methylsulfonylmethane (positive control) and FS (FS 100 mg/kg body weight [b.w.] and FS 300 mg/kg b.w.) effectively suppressed pathological changes in the knee joint and inhibited changes in the architectural and mineralization parameters. In addition, prostaglandin E2 (PGE2) and proinflammatory cytokines in the serum and catabolic factors, including matrix metalloproteinase (MMP)-3 and MMP-7 in articular cartilage, were decreased by dietary supplementation with FS in MIA-induced osteoarthritis. Based on these findings, we suggest that FS can be used for the development of potential therapies for osteoarthritis.

中文翻译：

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含有发酵牛膝的混合物在单碘乙酸酯注射的大鼠的膝关节中改善了骨关节炎。

我们证明了含有发酵的牛膝的混合物的效果Nakai（FS）在碘乙酸单钠（MIA）诱导的骨关节炎动物模型的背景下。MIA给药后，测量了大鼠的矿化，合成代谢和分解代谢因子以及关节软骨内的细胞因子含量。我们发现，饮食中补充甲磺酰甲烷（阳性对照）和FS（FS 100 mg / kg体重[bw]和FS 300 mg / kg bw）可有效抑制膝关节的病理变化，并抑制建筑和矿化参数的变化。此外，在MIA诱发的骨关节炎中，饮食中添加FS可以降低血清中的前列腺素E2（PGE2）和促炎细胞因子以及包括软骨中基质金属蛋白酶（MMP）-3和MMP-7在内的分解代谢因子。根据这些发现，