Tuberculosis is a worldwide health concern and isoniazid is the most used and considered one of the most effective drugs for its treatment. The “quality” concept must be incorporated into the final pharmaceutical product, according to the quality by design (QbD) definition. Therefore, the determination of analytical test conditions is extremely important and the design of experiments (DoE) becomes a very useful tool.

中文翻译：

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设计分析质量是确定异烟肼及其琥珀酰前药最佳分析条件的重要工具

结核病是世界范围内对健康的关注，异烟肼是使用最广泛，被认为是最有效的药物之一。根据设计质量（QbD）定义，“质量”概念必须纳入最终药品中。因此，确定分析测试条件非常重要，并且实验设计（DoE）成为非常有用的工具。