Carbohydrate antigen 125 (CA125) is a congestion and inflammation biomarker and has been proved to be related to a worse prognosis in heart diseases. However, the precise relationship between elevated CA125 in patients with ST-segment elevation myocardial infarction (STEMI) has not yet been sufficiently studied. We set out to determine the association of CA125 with all-cause mortality at 6 months in STEMI. CA125, N-terminal pro brain natriuretic peptide (NTproBNP) and high sensitive C-reactive protein (hs-CRP) were measured in 245 patients admitted consecutively with STEMI undergoing coronary angioplasty. The mean age in our sample was 63.7 years, 64.9% were males, 28.3% had diabetes and 17.7% presented with acute heart failure (Killip ≥ 2). The median serum level of CA125 was 8.1 U/ml. At 6 months, the rate of all-cause mortality was 18% (44 patients). Receiver operating characteristic curve analysis demonstrated that CA125 presented similar performance to predict mortality as NTproBNP and hs-CRP. Patients with CA125 ≥ 11.48 had a higher rate of mortality (Hazard Ratio = 2.07, 95% confidence interval = 1.13–3.77, p = 0.017) than patients with CA125 < 11.48. This study suggests that elevated CA125 levels might be used to identify patients with STEMI with a higher risk of death at 6 months. CA125 seems to be a similar predictor of mortality compared to NTproBNP and hs-CRP.

碳水化合物抗原 125 (CA125) 是一种充血和炎症生物标志物，已被证明与心脏病的较差预后有关。然而，ST段抬高型心肌梗死（STEMI）患者CA125升高之间的确切关系尚未得到充分研究。我们着手确定 CA125 与 STEMI 6 个月全因死亡率的关联。对 245 名连续入院接受冠状动脉血管成形术的 STEMI 患者进行 CA125、N 端脑钠肽前体 (NTproBNP) 和高敏 C 反应蛋白 (hs-CRP) 检测。我们样本的平均年龄为 63.7 岁，64.9% 为男性，28.3% 患有糖尿病，17.7% 患有急性心力衰竭（Killip ≥ 2）。CA125 的中位血清水平为 8.1 U/ml。6 个月时，全因死亡率为 18%（44 名患者）。受试者工作特征曲线分析表明，CA125 在预测死亡率方面表现出与 NTproBNP 和 hs-CRP 相似的性能。 CA125 ≥ 11.48 的患者比 CA125 < 11.48 的患者死亡率更高（风险比 = 2.07，95% 置信区间 = 1.13–3.77，p = 0.017）。这项研究表明，升高的 CA125 水平可用于识别 6 个月时死亡风险较高的 STEMI 患者。与 NTproBNP 和 hs-CRP 相比，CA125 似乎是类似的死亡率预测因子。