This case–control study compared the body composition, resting metabolic rate (RMR), and respiratory quotient (RQ) of narcolepsy patients with those of body mass index (BMI)- gender and age-matched controls. This study included 14 male patients with narcolepsy and 14 matched controls. The narcolepsy patients were subdivided into two subgroups (n = 7/each): those with cataplexy (NT1) and those without cataplexy (NT2). Anthropometric measurements, bioelectric impedance analysis, and indirect calorimetry were used in addition to the calculation of common body-composition indices (conicity index, abdominal volume index, and body adiposity index). Our results showed no significant difference in fat percentage, fat mass, fat-free mass, and TBW among NT1, NT2, and controls (p > 0.05). Compared to matched controls, there was a reduction of muscle mass in both NT1 and NT2 subgroups. The RMR was similar in all groups, while patients in the NT1/NT2 subgroups had a lower RQ, used more fat and fewer carbohydrates during the fasting period. These findings give an insight into the distinctive state of altered metabolism in patients with narcolepsy, especially the resting metabolic rate, which was not altered in NT1 vs. NT2 compared to the controls when matched for BMI, age, and gender.

这项病例对照研究将发作性睡病患者的身体成分，静息代谢率（RMR）和呼吸商（RQ）与体重指数（BMI），性别和年龄匹配的对照进行了比较。这项研究包括14例发作性睡病的男性患者和14例相匹配的对照组。发作性睡病患者分为两个亚组（n = 7 /每组）：患有脑瘫的患者（NT1）和没有脑瘫的患者（NT2）。除了计算常见的身体成分指数（锥度指数，腹部体积指数和身体肥胖指数）外，还使用人体测量，生物电阻抗分析和间接量热法。我们的研究结果显示，NT1，NT2和对照组的脂肪百分比，脂肪质量，无脂肪质量和TBW均无显着差异（p > 0.05）。与配对对照组相比，NT1和NT2亚组的肌肉质量均降低。在所有组中，RMR相似，而在NT1 / NT2亚组中，患者的RQ较低，在禁食期间消耗更多的脂肪和更少的碳水化合物。这些发现为发作性睡病患者的新陈代谢变化的独特状态提供了见识，尤其是静息代谢率，在与BMI，年龄和性别相匹配的情况下，与对照组相比，NT1 vs.NT2并没有改变。