Polycyclic xanthones are secondary metabolites from actinomycetes and cervinomycin A and B are bioactive 26-membered polycyclic xanthones from Streptomyces sp. CPCC 204980. Herein, we report cervinomycins C_1-4 (1–4) from the same strain. The structures of 1–4 were determined by 1D- and 2D-NMR, or single-crystal X-ray diffraction. Compounds 1–4 feature the open or loss of A (oxazolidine) ring in their angular polycyclic framework compared with cervinomycin B. Compounds 1–4 showed potent cytotoxicity against human cancer cell lines HCT116 and BxPC-3, with IC₅₀ at 0.9–801.0 nM and strong anti-Gram-positive bacterial activity.

多环氧杂蒽酮是放线菌的次生代谢产物，头孢霉素A和B是链霉菌属的具有生物活性的26元多环氧杂蒽酮。CPCC 204980.此，我们报告cervinomycinsÇ _1-4（1 - 4）从相同菌株中。的结构1 - 4通过1D-和2D-NMR，或单晶X射线衍射来确定。化合物1 - 4特征的开放或在它们的角的多环骨架A（恶唑烷）环的损耗相比cervinomycin B.化合物1 - 4显示出对人癌症细胞系HCT116和BxPC-3的细胞毒性，与IC ₅₀ 在0.9–801.0 nM时具有很强的抗革兰氏阳性细菌活性。