FBXO protein 45 (FBXO45), a substrate-recognition subunit of E3 ligases, has been characterised to have pivotal roles in many human diseases, including nervous system diseases, inflammatory diseases and human malignancies. In this article, we describe the expression of FBXO45 in several types of human tumour specimens and highlight the downstream substrates of FBXO45. Moreover, the biological functions of FBXO45 in the regulation of proliferation, apoptosis, the cell cycle and metastasis are mentioned. Furthermore, we describe that the expression level of FBXO45 is regulated by several upstream factors such as miR-27a, Hey1, m⁶A and the lncRNA RP11. As FBXO45 has a critical role in tumorigenesis and progression, FBXO45 might be a novel therapeutic target for cancer treatment.

FBXO 蛋白 45 (FBXO45) 是 E3 连接酶的底物识别亚基，已被证实在许多人类疾病中发挥着关键作用，包括神经系统疾病、炎症性疾病和人类恶性肿瘤。在本文中，我们描述了 FBXO45 在几种类型的人类肿瘤标本中的表达，并重点介绍了 FBXO45 的下游底物。此外，还提到了FBXO45在调节增殖、凋亡、细胞周期和转移方面的生物学功能。此外，我们描述了 FBXO45 的表达水平受到几个上游因子的调节，例如 miR-27a、Hey1、m ⁶ A 和 lncRNA RP11。由于FBXO45在肿瘤发生和进展中具有关键作用，因此FBXO45可能成为癌症治疗的新治疗靶点。