The simple pseudo four-component reaction of 2,7-naphthalenediol, tow molecules of aldehydes and ammonum carboxylates to produce a series of N-acylated and non-acylated highly substituted piperidine derivatives has been carried out in the presence of choline chloride/urea at 80 °C. One-pot reaction, high efficiency, appropriate reaction time, and easy purification of products by simple recrystallization are some of the considerable advantages of this procedure. The produced highly substituted piperidine derivatives were screened for their antioxidant property. The results indicated that the highly substituted piperidine derivative 4h had higher antioxidant properties.

2，7-萘二醇，醛的两个分子和羧酸铵的简单的假四组分反应在一系列氯化胆碱/尿素的存在下进行了N-酰化和非酰化的高度取代的哌啶衍生物的合成。 80℃。一锅法反应，高效，适当的反应时间以及通过简单的重结晶即可轻松纯化产物的方法，是该方法的显着优势。筛选产生的高度取代的哌啶衍生物的抗氧化性能。结果表明，高度取代的哌啶衍生物4h具有较高的抗氧化性能。