Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation.

布洛芬是儿科实践中最常用的抗炎药之一。该药物抑制环氧合酶，减少前列腺素的产生，而前列腺素是男性生殖功能的重要介体。我们检查了布洛芬对雄性大鼠的青春期前治疗是否会影响这些动物在成年生活中及其后代的生殖参数。雄性大鼠（23天大）从出生后（PND）23到53，每次管饲接受布洛芬（0; 2.4; 7.2或14.3 mg / kg /天）。在性成熟时，将经过治疗的雄性与未经治疗的雌性放在一起以获取下一代（F1）。最高剂量的布洛芬会干扰性行为，并降低这些动物成年后的生育能力。此外，布洛芬治疗改变了精子的数量和质量，如精子活力下降和睾丸每日精子产量减少所证明。青春期前的治疗也可降低睾丸激素水平。用这种药物进行的父亲治疗也影响了子代的生殖结果。雄性后代的雄性后代在附睾中的精子传递时间加快，Leydig细胞核的数量和体积减少，而雌性后代表现出发情的周期性，生育力降低。青春期前布洛芬治疗对成年造成不利的生殖影响，损害精子的质量和数量，并干扰下一代的生殖结果。用这种药物进行的父亲治疗也影响了子代的生殖结果。雄性后代的雄性后代在附睾中的精子转运时间加快，Leydig细胞核的数量和体积减少，而雌性后代表现出发情周期性，生育力降低。青春期前布洛芬治疗对成年造成不利的生殖影响，损害精子的质量和数量，并干扰下一代的生殖结果。用这种药物进行的父亲治疗也影响了子代的生殖结果。雄性后代的雄性后代在附睾中的精子转运时间加快，Leydig细胞核的数量和体积减少，而雌性后代表现出发情周期性，生育力降低。青春期前布洛芬治疗对成年造成不利的生殖影响，损害精子的质量和数量，并干扰下一代的生殖结果。雌性后代表现出发情周期，生育潜力降低。青春期前布洛芬治疗对成年造成不利的生殖影响，损害精子的质量和数量，并干扰下一代的生殖结果。雌性后代表现出发情周期，生育潜力降低。青春期前布洛芬治疗对成年造成不利的生殖影响，损害精子的质量和数量，并干扰下一代的生殖结果。