Abstract

A new aurone named (2Z)-2-[(4’-hydroxy-3’-methoxyphenyl) methylene]-6-methoxy-7-prenyl-3(2H)-benzofurane (1), together with five known compounds (2–6), were isolated from EtOAc-soluble extract of the stems of Acanthopanax senticosus. The chemical structures were elucidated on the basis of spectroscopic analyses. All isolates were evaluated for in vitro inhibitory activity on α-glucosidase. Among them, compounds 1 and 4 were found to exhibit moderate inhibitory activity on α-glucosidase with IC₅₀ value of 64.1 ± 1.2 and 48.9 ± 1.1 μM, respectively.

中文翻译：

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刺五加茎的化学成分及其对α-葡萄糖苷酶的抑制活性

摘要

一种名为 (2 Z )-2-[(4'-羟基-3'-甲氧基苯基) 亚甲基]-6-甲氧基-7-异戊二烯基-3(2 H )-苯并呋喃 ( 1 ) 的新金酮，以及五种已知化合物( 2–6 )，是从刺五加茎的 EtOAc 可溶性提取物中分离出来的。在光谱分析的基础上阐明了化学结构。评估所有分离株对α-葡萄糖苷酶的体外抑制活性。其中，化合物1和4对α-葡萄糖苷酶表现出中等抑制活性，IC ₅₀值分别为64.1 ± 1.2和48.9 ± 1.1 μM。