Abstract

A new prenylated coumestan, campylohirtin A (1), along with fifteen phenolic known compounds (2‒16) and four other known compounds (17‒20), was obtained from the 95% ethanol extract of roots of Campylotropis hirtella. Their structures were elucidated based on extensive spectroscopic analysis (1 D and 2 D-NMR, MS, UV and IR). In vitro antimalarial activities of compounds 1−3, 5−14 and 16 were evaluated by β-hematin formation inhibition assay. Compared with the positive control chloroquine diphosphate, compounds 8, 11 and 16 exhibited strong antimalarial activity with the IC₅₀ values of 69.9, 33.2 and 75.4 µM, respectively. Compounds 1−3, 5−7 and 12 showed moderate antimalarial activities with IC₅₀ values ranging from 134.6 µM to 578.6 µM.

摘要

从Campylotropis hirtella根的 95% 乙醇提取物中获得了一种新的异戊烯化香豆素，campylohirtin A ( 1 )，以及 15 种酚类已知化合物 ( 2-16 ) 和其他四种已知化合物 ( 17-20 ) 。基于广泛的光谱分析（1 D 和 2 D-NMR、MS、UV 和 IR）阐明了它们的结构。体外化合物的抗疟疾活性1 - 3，5 - 14和16是由评价β -hematin形成抑制测定法。与阳性对照二磷酸氯喹相比，化合物8，11和16表现出很强的抗疟活性，IC ₅₀值分别为 69.9、33.2 和 75.4 µM。化合物1 - 3，5 - 7个12表现出中等带IC抗疟疾活性_50个值范围从134.6至μMμM578.6。