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Analysis of ACE2 Gene-Encoded Proteins Across Mammalian Species.
Frontiers in Veterinary Science ( IF 3.2 ) Pub Date : 2020-06-22 , DOI: 10.3389/fvets.2020.00457
Ying Cao 1, 2, 3 , Yeping Sun 1 , Xiaodong Tian 1 , Zhihua Bai 1, 4 , Yue Gong 5 , Jianxun Qi 1 , Di Liu 2, 4 , Wenjun Liu 1, 4, 6 , Jing Li 1, 4
Affiliation  

Human beings are currently experiencing a serious public health event. Novel coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2), has infected about 3 million people worldwide and killed more than 200,000, most being the elderly or people with potential chronic diseases or in immunosuppressive states. According to big data analysis, there are many proteins homologous to or interacting with the angiotensin-converting enzyme 2 (ACE2), which, therefore, may not be the only receptor for the novel coronavirus; other receptors may also exist in host cells of different species. These potential receptors may also play an important role in the infection process of the novel coronavirus. The current study aimed to discover such key proteins or receptors and analyze the susceptibility of different animals to the novel coronavirus, in order to reveal the transmission process of the virus in cross-species infection. We analyzed the proteins coded by the ACE2 gene in different mammalian species and predicted their correlation and homology with the human ACE2 receptor. The major finding of our predictive analysis suggested ACE2 gene-encoded proteins to be highly homologous across mammals. Based on their high homology, their possibility of binding the spike-protein of SARS-CoV-2 is quite high and species such as Felis catus, Bos taurus, Rattus norvegicus etc. may be potential susceptible hosts; special monitoring is particularly required for livestock that are in close contact with humans. Our results might provide ideas for the prevention and control of the novel coronavirus pneumonia.



中文翻译:

跨哺乳动物物种的ACE2基因编码蛋白分析。

人类目前正在经历严重的公共卫生事件。由新型严重急性呼吸系统综合症冠状病毒(SARS-CoV-2)引起的新型冠状病毒病2019(COVID-19)已感染全球约300万人,并杀死了200,000多人,其中大多数是老年人或潜在慢性病患者或处于免疫抑制状态。根据大数据分析,有许多与血管紧张素转换酶2(ACE2)同源或相互作用的蛋白质,因此,可能不是新型冠状病毒的唯一受体。其他受体也可能存在于不同物种的宿主细胞中。这些潜在的受体也可能在新型冠状病毒的感染过程中发挥重要作用。目前的研究旨在发现这种关键蛋白或受体,并分析不同动物对新型冠状病毒的敏感性,以揭示该病毒在跨物种感染中的传播过程。我们分析了由ACE2基因编码的蛋白在不同的哺乳动物物种中,并预测了它们与人ACE2受体的相关性和同源性。我们的预测分析的主要发现表明,ACE2基因编码的蛋白在哺乳动物之间具有高度同源性。基于它们的高度同源性,它们结合SARS-CoV-2突突蛋白的可能性非常高,诸如Felis catus,Bos taurus,Rattus norvegicus等物种可能是潜在的易感宿主。与人类密切接触的牲畜特别需要特殊监控。

更新日期:2020-07-03
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