Background: The John Cunningham virus (JCV) is the causative agent of progressive multifocal leukoencephalopathy. Anti-JCV antibody seropositivity is an important consideration in patients with multiple sclerosis (MS). The reported prevalence of JCV in MS patients has been conflicting. Objective: We aimed to conduct a systematic review and meta-analysis to estimate the pooled prevalence of anti-JCV antibody seropositivity in cases with MS. Methods: We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, ProQuest, Google Scholar, and gray literature including reference of included studies, and conference abstracts which were published up to April 2019. Two independent researchers independently assessed the articles. Results: The literature search found 181 articles. After eliminating duplicates, reviews, case reports, and trials, 15 articles remained. Finally, 8 articles were included for the final analysis (from Asia, Europe, the USA, and Canada). In total, 16,041 MS cases were analyzed. The prevalence of anti-JCV antibody seropositivity varied between 40 and 80%, and the pooled estimate was calculated as 60% (95% CI: 56–64%), though with significant heterogeneity (I² = 95%, p = 0.01). Conclusion: The prevalence of anti-JCV antibody seropositivity is variable among MS patients in different countries, and the pooled estimate showed that this is 60% overall.
Intervirology

中文翻译：

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多发性硬化症患者中抗JC病毒抗体阳性的流行：系统评价和荟萃分析。

背景：约翰·坎宁安病毒（JCV）是进行性多灶性白质脑病的病原体。抗JCV抗体血清阳性是多发性硬化症（MS）患者的重要考虑因素。据报道，MS患者中JCV的患病率一直存在矛盾。目的：我们旨在进行系统的回顾和荟萃分析，以评估MS患者抗JCV抗体血清阳性的合并患病率。方法：我们检索了截至2019年4月发表的PubMed，Scopus，EMBASE，CINAHL，Web of Science，Ovid，ProQuest，Google Scholar和灰色文献，包括纳入研究的参考文献和会议摘要。两名独立研究人员对文章进行了独立评估。结果：文献检索发现181篇文章。消除重复，复审，病例报告和审判后，剩下15篇文章。最后，包括8篇文章进行最终分析（来自亚洲，欧洲，美国和加拿大）。总共分析了16,041例MS病例。抗JCV抗体血清阳性的患病率在40％至80％之间变化，汇总估计值计算为60％（95％CI：56–64％），尽管存在明显的异质性（I ² = 95％，p = 0.01） 。结论：抗JCV抗体血清阳性的发生率在不同国家的MS患者之间是可变的，汇总的估计显示，总体而言，这一比例为60％。
病毒学