Several simple and prenylated coumarin derivatives were isolated from the dichloromethane extract of the root of Neocryptodiscus papillaris based on moderate cytotoxic activity of the extract in COLO205, KM12 and MCF7 cancer cells. While the major prenylated furanocoumarin derivatives and osthol isolated from the dichloromethane extract were responsible for the activity in the colon and breast cancer cell lines, the 4′-acylated osthol derivatives including a novel coumarino-alkaloid; neopapillarine) demonstrated selective cytotoxic activity in A498 and UO31 renal cancer cell lines.

中文翻译：

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Neopapillarine，一种不寻常的香豆素生物碱，来自 Neocryptodiscus papillaris 的根提取物，对肾癌细胞具有细胞毒活性

基于提取物在 COLO205、KM12 和 MCF7 癌细胞中的中等细胞毒活性，从新隐盘藻根的二氯甲烷提取物中分离出几种简单的异戊二烯化香豆素衍生物。虽然从二氯甲烷提取物中分离出的主要异戊二烯化呋喃香豆素衍生物和蛇床子酚在结肠和乳腺癌细胞系中具有活性，但 4'-酰化蛇床子素衍生物包括一种新型香豆素生物碱；Neopapilline) 在 A498 和 UO31 肾癌细胞系中表现出选择性细胞毒活性。