The aim of the study was to determine the relationships between maternal smoking, total adiponectin, high molecular weight adiponectin (HMW adiponectin), selected somatomedins, and the birth weight of newborns. A total of 78 women with a healthy, singleton pregnancy, 41 active smokers and 37 non-smokers, and their offspring were studied. Total and HMW adiponectin, insulin-like growth factor I (IGF-I), and insulin-like growth factor binding protein-1 (IGFBP-1) and 2 (IGFBP-2) were determined in maternal and cord blood by enzyme-link immunosorbent assay. Serum levels of total and HMW adiponectin were lower in smokers compared to the tobacco abstinent in both the mothers (p = 0.013; p = 0.006) and the infants (p = 0.001; p = 0.047). In smoking women and their children, serum concentrations of IGF-I were significantly lower (p = 0.014; p = 0.042), IGFBP-1 significantly higher (p = 0.009; p = 0.039), and IGFBP-2 did not differ from that observed in the non-smoking group. In multivariate analysis performed on the whole group of mothers, the highest impact of serum cotinine and IGFBP-2 levels were indicated for adiponectin and cotinine and the number of cigarettes/day for HMW adiponectin concentration. In correlation analysis estimated separately for smokers and non-smokers, neonatal birth weight was positively associated with total and HMW adiponectin concentrations in umbilical cord blood. Birth weight was also inversely associated with IGFBP-1 and positively correlated with IGF-I levels in maternal serum as well as in cord blood (r = −0.317, p = 0.005; r = −0.294, p = 0.004; r = 0.245, p = 0.031; r = 0.271, p = 0.009, respectively). The present study showed the levels of total and HMW adiponectin in umbilical cord blood may have a significant effect on fetal development. Both IGF-I and IGFBP-1 concentrations also play an essential role in fetal growth, which is an important predictor of birth weight. Cigarette smoking during pregnancy negatively affected adiponectin and the insulin growth factor profile in the serum of women and the cord blood and may be the reason for the lower birth weight of the smokers newborns compared with the nonsmokers offspring.

中文翻译：

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吸烟和非吸烟母亲的总脂联素，高分子量脂联素，精选的Somatomedins和出生体重之间的母婴关系。

该研究的目的是确定孕产妇吸烟，总脂联素，高分子量脂联素（HMW脂联素），精选的植脂素与新生儿出生体重之间的关系。研究了总共78名健康，单身妊娠的妇女，41名积极吸烟者和37名不吸烟者及其后代。通过酶联法测定母体和脐带血中总和HMW脂联素，胰岛素样生长因子I（IGF-1）和胰岛素样生长因子结合蛋白1（IGFBP-1）和2（IGFBP-2）。免疫吸附测定。与母亲戒烟（p = 0.013；p = 0.006）和婴儿戒烟（p = 0.001；p）相比，吸烟者的血清总和HMW脂联素水平均较低。= 0.047）。在吸烟妇女及其子女中，IGF-I的血清浓度显着降低（p = 0.014； p = 0.042），IGFBP-1显着较高（p = 0.009; p= 0.039），而IGFBP-2与非吸烟组中观察到的无差异。在对整个母亲组进行的多变量分析中，脂联素和可替宁的血清可替宁和IGFBP-2水平的影响最高，而HMW脂联素的浓度则表明每天吸烟的数量。在对吸烟者和非吸烟者分别进行的相关性分析中，新生儿出生体重与脐带血中总和HMW脂联素浓度呈正相关。出生体重也与孕产妇血清以及脐带血中的IGFBP-1呈负相关，与IGF-I水平呈正相关（r = -0.317，p = 0.005; r = -0.294，p = 0.004; r = 0.245，p = 0.031； r ​​= 0.271，p分别为0.009）。本研究显示脐带血中总脂联素和HMW脂联素的水平可能对胎儿发育有重要影响。IGF-1和IGFBP-1的浓度在胎儿生长中也起着至关重要的作用，这是出生体重的重要预测指标。怀孕期间吸烟对妇女血清和脐带血中的脂联素和胰岛素生长因子谱具有负面影响，并且可能是吸烟者新生儿出生体重较非吸烟者后代低的原因。