Partial clinical remission (PCR) is a transitory period characterized by the residual endogenous insulin secretion following type 1 diabetes (T1D) diagnosis and introducing the insulin therapy. Scientific interest in PCR has been recently increasing, as this phase could be crucial to preserve functional beta cells after T1D onset, also taking advantage of new therapeutic opportunities. The aim of this study was to assess the frequency, duration and associated factors of PCR in children newly diagnosed with T1D. Our cohort study included 167 pediatric patients aged 13.8 ± 4.1 years. The association of clinical and laboratory factors with the occurrence and duration of PCR was evaluated via logistic regression and multivariable generalized linear model, respectively. PCR occurred in 63.5% of the examined patients. Patients who achieved the remission phase were significantly older, and they had lower daily insulin requirement compared with non-remitters. PCR was positively associated to body mass index (OR = 1.11; p = 0.032), pH value (OR 49.02; p = 0.003) and c-peptide levels (OR 12.8; p = 0.002). The average duration of PCR was 13.4 months, and older age at diagnosis was the only predictor factor. Two years after diagnosis remitter patients had lower HbA1c and daily insulin requirement.

中文翻译：

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年龄对新诊断的1型糖尿病儿童部分临床缓解的影响。

部分临床缓解（PCR）是一个过渡期，其特征在于1型糖尿病（T1D）诊断并引入胰岛素治疗后残留的内源性胰岛素分泌。最近对PCR的科学兴趣不断增强，因为这一阶段对于T1D发作后保存功能性β细胞至关重要，同时也利用了新的治疗机会。这项研究的目的是评估新诊断为T1D的儿童中PCR的频率，持续时间和相关因素。我们的队列研究包括167名13.8±4.1岁的小儿患者。通过logistic回归和多变量广义线性模型分别评估临床和实验室因素与PCR发生和持续时间的相关性。在检查的患者中有63.5％发生了PCR。达到缓解期的患者年龄较大，与非缓解期患者相比，他们的每日胰岛素需求量更低。PCR与体重指数呈正相关（OR = 1.11；p = 0.032），pH值（OR 49.02；p = 0.003）和c肽水平（OR 12.8；p = 0.002）。PCR的平均持续时间为13.4个月，诊断时的年龄是唯一的预测因素。诊断后两年，患者的HbA1c和每日胰岛素需求量较低。