We report a case of an 8-year-old girl who underwent a SARS-CoV-2 infection manifesting with atypical symptoms spearheaded by abdominal discomfort and systemic inflammation and partially mimicking hemophagocytic lymphohistiocytosis (HLH) or macrophage activation syndrome (MAS), which however did not fulfill the HLH/MAS diagnostic criteria. In this case of what has since been described as Pediatric Inflammatory Multisystem Syndrome Temporally associated with SARS-COV-2 (PIMS-TS) we documented excellent clinical response to immunosuppression with systemic corticosteroids and intravenous immunoglobulins. We show a detailed longitudinal development of neutrophil immunophenotype which suggests activation and engagement of neutrophils during PIMS-TS with compensatory contraction of the response and contra-regulation of neutrophil phenotype during recovery.

我们报告了一例8岁的女孩，她经历了SARS-CoV-2感染，表现出由腹部不适和全身性炎症带头的非典型症状，并且部分模仿了噬血细胞淋巴组织细胞增生症（HLH）或巨噬细胞活化综合征（MAS），不符合HLH / MAS诊断标准。在此后被称为与SARS-COV-2（PIMS-TS）暂时相关的小儿炎症多系统综合征的病例中，我们记录了对全身性皮质类固醇和静脉内免疫球蛋白免疫抑制的出色临床反应。