Four new chiral α‐(nonafluoro‐tert‐butoxy)carboxylic acids were synthesized from naturally occurring α‐amino acids (alanine, valine, leucine and isoleucine, respectively), and tested in ¹H‐ and ¹⁹F‐NMR experiments as chiral NMR shift reagents. The NMR studies were carried out at room temperature, using CDCl₃ and C₆D₆ as solvents, and (RS)‐α‐phenylethylamine and (RS)‐α‐(1‐naphthyl)ethylamine as racemic model compounds. To demonstrate the applicability of the reagents, the racemic drugs ketamine and prasugrel were also tested.

中文翻译：

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基于手性α氨基酸的核磁共振溶剂

从天然存在的α-氨基酸（分别为丙氨酸，缬氨酸，亮氨酸和异亮氨酸）合成了四种新的手性α-（九氟叔丁氧基）羧酸，并在¹ H -NMR和¹⁹ F-NMR实验中进行了手性NMR测试转移试剂。NMR研究是在室温下进行的，使用CDCl ₃和C ₆ D ₆作为溶剂，并使用（RS）-α-苯乙胺和（RS）-α-（1-萘基）乙胺作为外消旋模型化合物。为了证明该试剂的适用性，还测试了外消旋药物氯胺酮和普拉格雷。