Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional‐defiant disorder, antisocial personality disorder, kleptomania, pyromania and other illnesses. Although they all share a common feature (aberrant impulsivity), their pathobiology is complex and poorly understood. There are also currently no ICD‐specific therapies to treat these illnesses. Animal models are a valuable tool for studying ICD pathobiology and potential therapies. The zebrafish (Danio rerio) has become a useful model organism to study CNS disorders due to high genetic and physiological homology to mammals, and sensitivity to various pharmacological and genetic manipulations. Here, we summarize experimental models of impulsivity and ICD in zebrafish and highlight their growing translational significance. We also emphasize the need for further development of zebrafish ICD models to improve our understanding of their pathogenesis and to search for novel therapeutic treatments.

中文翻译：

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冲动和冲动控制障碍的斑马鱼模型

冲动控制障碍（ICD）的特征是难以控制情绪和行为。ICD是广泛的中枢神经系统（CNS）疾病，包括行为障碍，间歇性爆炸，对立违抗性疾病，反社会人格障碍，盗窃癖，发热症和其他疾病。尽管它们都有一个共同的特征（异常冲动），但它们的病理生物学却很复杂，并且了解甚少。当前也没有治疗这些疾病的ICD专用疗法。动物模型是研究ICD病理生物学和潜在疗法的宝贵工具。斑马鱼（Danio rerio）由于与哺乳动物的高度遗传和生理同源性以及对各种药理和遗传操作的敏感性，已成为研究中枢神经系统疾病的有用模式生物。在这里，我们总结了斑马鱼冲动性和ICD的实验模型，并突出了它们日益重要的翻译意义。我们还强调需要进一步开发斑马鱼ICD模型，以增进我们对斑马鱼发病机理的了解，并寻求新颖的治疗方法。