Cover story

Our cover features an H&E stained tissue section from the lung of mice after repeated intranasal administration of live Aspergillus fumigatus conidia. The left part of the picture shows germinated conidia and several inflammatory cell types including eosinophils and large activated macrophages. This model of allergic lung inflammation is used in Dietschmann et al. (pp. 1044–1056), where the authors demonstrate a critical role of Th2 cell‐derived IL‐4/IL‐13 for eosinophilia and inflammation of the lung. The authors further show that eosinophil‐deficient ΔdblGata mice contain fewer Th2 cells in the lung parenchyma but mount a similar inflammatory response in the lung.

中文翻译：

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封面故事

我们的覆盖物具有重复性鼻内施用活烟曲霉分生孢子的小鼠肺部H＆E染色组织切片。图片的左侧显示了分生孢子和几种炎性细胞类型，包括嗜酸性粒细胞和大型活化的巨噬细胞。Dietschmann等人（2002年）使用这种过敏性肺部炎症模型。（第1044-1056页），作者证明了Th2细胞来源的IL-4 / IL-13在嗜酸性粒细胞增多和肺部炎症中起关键作用。作者进一步证明，缺乏嗜酸性粒细胞的ΔdblGata小鼠在肺实质中含有较少的Th2细胞，但在肺中却具有类似的炎症反应。