Association between METTL3 gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study.,Journal of Cellular and Molecular Medicine

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Association between METTL3 gene polymorphisms and neuroblastoma susceptibility: A nine-centre case-control study.
Journal of Cellular and Molecular Medicine ( IF 5.3 ) Pub Date : 2020-07-02 , DOI: 10.1111/jcmm.15576
Jun Bian ₁ , Zhenjian Zhuo ₂ , Jinhong Zhu ₃ , Zhonghua Yang ₄ , Zhang Jiao ₅ , Yong Li ₆ , Jiwen Cheng ₇ , Haixia Zhou ₈ , Suhong Li ₉ , Li Li ₁₀ , Jing He ₂ , Yanfei Liu ₁

Affiliation

Department of General Surgery, Xi'an Children's Hospital, Xi'an Jiaotong University Affiliated Children's Hospital, Xi'an, China.
Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Department of Clinical Laboratory, Biobank, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Pediatric Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Pediatric Surgery, Hunan Children's Hospital, Changsha, China.
Department of Pediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Hematology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Pathology, Children Hospital and Women Health Center of Shanxi, Taiyuan, China.
Kunming Key Laboratory of Children Infection and Immunity, Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Institute of Pediatrics Research, Yunnan Medical Center for Pediatric Diseases, Kunming Children's Hospital, Kunming, China.

Neuroblastoma ranks as the most commonly seen and deadly solid tumour in infancy. The aberrant activity of m⁶A‐RNA methyltransferase METTL3 is involved in human cancers. Therefore, functional genetic variants in the METTL3 gene may contribute to neuroblastoma risk. In the current nine‐centre case‐control study, we aimed to analyse the association between the METTL3 gene single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility. We genotyped four METTL3 gene SNPs (rs1061026 T>G, rs1061027 C>A, rs1139130 A>G, and rs1263801 G>C) in 968 neuroblastoma patients and 1814 controls in China. We found significant associations between these SNPs and neuroblastoma risk in neither single‐locus nor combined analyses. Interestingly, in the stratified analysis, we observed a significant risk association with rs1061027 AA in subgroups of children ≤ 18 months of age (adjusted OR = 1.87, 95% CI = 1.03‐3.41, P = .040) and females (adjusted OR = 1.86, 95% CI = 1.07‐3.24, P = .028). Overall, we identified a significant association between METTL3 gene rs1061027 C>A polymorphism and neuroblastoma risk in children ≤18 months of age and females. Our findings provide novel insights into the genetic determinants of neuroblastoma.

更新日期：2020-08-11

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