Gelatin capsules (GCs) with mean size between 200 and 400 nm are prepared via sonochemical method. Their size is low that the usual size for the sonochemically obtained protein capsules and depends on the preparation conditions. The nanometer size of GCs is explained by the low‐gelatin concentration and by the denaturated state of gelatin. The influence of pH, sonication time, and temperature on GCs size is investigated. An increase in temperature and sonication time results into GCs size increase. The pH dependence of GCs size passes through a minimum at the isoelectric point of gelatin. The broad size distribution detected by dynamic light scattering and scanning electron microscopy is explained by the broad molecular weight distribution of gelatin. GCs are successfully applied for encapsulation of two hydrophobic drugs, α‐tocopherol and acetylsalicylic acid, in order to demonstrate the versatility of the sonochemical method for drug encapsulation. In the case of α‐tocopherol drug entrapment efficiency as high as 95% is obtained.

中文翻译：

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通过声化学方法获得的明胶微胶囊和纳米胶囊

通过声化学方法制备平均大小在200至400 nm之间的明胶胶囊（GCs）。它们的尺寸小于超声化学获得的蛋白质胶囊的常规尺寸，并取决于制备条件。GCs的纳米尺寸由低明胶浓度和明胶的变性状态解释。研究了pH，超声处理时间和温度对GC尺寸的影响。温度和超声处理时间的增加导致GC尺寸增加。GC大小的pH依赖性在明胶的等电点处最小。通过动态光散射和扫描电子显微镜检测到的宽尺寸分布由明胶的宽分子量分布解释。GC成功应用于两种疏水性的封装药物，如α-生育酚和乙酰水杨酸，以证明声化学方法用于药物封装的多功能性。对于α-生育酚，药物的包封率高达95％。