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Morphological Profiling Identifies a Common Mode of Action for Small Molecules with Different Targets.
ChemBioChem ( IF 3.2 ) Pub Date : 2020-07-03 , DOI: 10.1002/cbic.202000381
Tabea Schneidewind 1, 2 , Alexandra Brause 1 , Axel Pahl 1 , Annina Burhop 1 , Tom Mejuch 1 , Sonja Sievers 1 , Herbert Waldmann 1, 2 , Slava Ziegler 1
Affiliation  

Route planner: We explored a morphology‐based cluster around the iron chelator deferoxamine by using the cell painting assay and identified annotated compounds with different targets but a similar mode of action. This cluster can be used to predict modes of action for unexplored small molecules, thus highlighting the value of morphological profiling to explore the bioactivity of compound collections.
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中文翻译:

形态分析确定了具有不同靶点的小分子的共同作用模式。

路线规划器:我们通过使用细胞绘制测定法探索了铁螯合剂去铁胺周围基于形态的簇,并鉴定了具有不同靶标但作用模式相似的注释化合物。该簇可用于预测未探索的小分子的作用模式,从而突出形态学分析对于探索化合物集合的生物活性的价值。
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更新日期:2020-07-03
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