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Impact of HLA polymorphisms among cadaveric donors on kidney graft allocation.
Transplant Immunology ( IF 1.5 ) Pub Date : 2020-07-03 , DOI: 10.1016/j.trim.2020.101318
Zorana Grubic 1 , Marija Burek Kamenaric 1 , Julijana Kljajic 1 , Katarina Stingl Jankovic 1 , Marija Maskalan 1 , Renata Zunec 1
Affiliation  

This study provides data on HLA-A, -B, and -DRB1 frequencies among 861 end-stage renal disease (ESRD) patients from Croatia and estimates the benefit of the kidney exchange program by comparing HLA distribution and assessing HLA mismatches (MMs) within a group of ESRD patients who received kidney grafts from 707 cadaveric donors (422 from Croatia and 285 from Eurotransplant).

Patients positive for HLA-B*07, -B*08, or -B*44 genes more often received a kidney from ET donors, while HLA-DRB1*11 and -DRB1*16 positive patients more frequently received a kidney from CRO donors.

ABDR MM 000 was more frequently present in the case of transplantation from ET donors, while MM 222 was significantly more frequent when the donor was from Croatia. Sensitized patients received kidney more frequently from ET donors (P < .0001). A large pool of organ donors with different HLA gene distributions allows for a higher probability of transplantation from HLA highly matched donor.



中文翻译:

尸体供体中HLA多态性对肾移植物分配的影响。

这项研究提供了来自克罗地亚的861名终末期肾病(ESRD)患者中HLA-A,-B和-DRB1频率的数据,并通过比较HLA分布和评估HLA不匹配(MM)评估了肾脏置换计划的益处一组ESRD患者接受了707名尸体捐赠者的肾脏移植(克罗地亚的422名和欧洲移植的285名)。

HLA-B * 07,-B * 08或-B * 44基因阳性的患者更经常从ET供体接受肾脏,而HLA-DRB1 * 11和-DRB1 * 16阳性的患者更经常从CRO供体接受肾脏。

从ET供体移植的情况下,出现ABDR MM 000的频率更高,而来自克罗地亚的捐献者的MM 222频率更高。过敏的患者从ET供体接受肾脏治疗的频率更高(P  <.0001)。具有不同HLA基因分布的大量器官供体使得从HLA高度匹配的供体移植的可能性更高。

更新日期:2020-07-03
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