Abstract The study was designed as a blinded, randomized, prospective, clinical trial to compare the use of 1% and 2% lignocaine hydrochloride for distal paravertebral nerve block in sheep undergoing Caesarian section. Full-term ewes (n = 18) with dystocia requiring laparohysterotomy were randomly and equally allotted to two groups (I and II). They were administered ceftriaxone (10 mg kg−1) and meloxicam (0.3 mg kg−1, IM) 30 min and diazepam (0.2 mg kg−1, IV) 15 min before injecting 15.0 mL (5.0 mL per spinal nerve) of either 1% (Group I) or 2% (Group II) lignocaine hydrochloride for achieving distal paravertebral anesthesia. Nociceptive stimuli during pre- and postoperative periods comprised of superficial and deep pinpricks. The reaction of the animals to the surgical intervention, manipulations and application of the sutures were recorded intraoperatively. Routine postoperative management included regular wound dressing, administration of the antibiotic and analgesic. The onset time (mean ± standard deviation) of the regional anesthesia in group I and II ewes was 4.6 ± 1.5 min and 5.4 ± 2.8 min respectively. One sheep per group showed temporary, mild muscle twitching near ventral flank but required no rescue analgesia. The duration of surgery was 52 ± 11 min and 60 ± 11 min and the anesthesia lasted for 87 ± 15 min and 98 ± 17 min respectively. Significant difference between the groups was not detected in any of these variables. From this clinical study it is concluded that satisfactory flank anesthesia is achieved using 2% or 1% lignocaine hydrochloride for distal paravertebral nerve block. The recommendation to use 1% instead of 2% local anesthetic preparation for safety in small ruminants is thus validated.

中文翻译：

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接受剖腹子宫切开术的绵羊远端椎旁神经阻滞：比较使用 1% 和 2% 盐酸利多卡因

摘要 本研究设计为一项盲法、随机、前瞻性临床试验，目的是比较 1% 和 2% 盐酸利多卡因用于剖腹产绵羊远端椎旁神经阻滞的效果。需要剖腹探查的难产的足月母羊（n = 18）被随机平均分配到两组（I和II）。在注射 15.0 mL（每条脊神经 5.0 mL）之前，给他们注射头孢曲松（10 mg kg-1）和美洛昔康（0.3 mg kg-1，IM）30 分钟和地西泮（0.2 mg kg-1，IV）15 分钟1%（I 组）或 2%（II 组）利多卡因盐酸盐用于实现远端椎旁麻醉。术前和术后期间的伤害性刺激包括浅层和深层针刺。动物对手术干预的反应，术中记录缝合线的操作和应用。常规术后管理包括定期伤口敷料、抗生素和镇痛药的使用。I组和II组母羊局部麻醉的起效时间（平均值±标准差）分别为4.6±1.5分钟和5.4±2.8分钟。每组一只羊在腹侧附近出现暂时的轻度肌肉抽搐，但不需要救援镇痛。手术时间分别为 52±11 分钟和 60±11 分钟，麻醉时间分别为 87±15 分钟和 98±17 分钟。在这些变量中的任何一个中都没有检测到组之间的显着差异。从这项临床研究得出的结论是，使用 2% 或 1% 盐酸利多卡因进行远端椎旁神经阻滞可以获得令人满意的腰部麻醉。