This study aimed to investigate the effects of alkaline agents on reducing strong inspiratory effort. Rabbits with hypercapnia or lung injury, induced via repeated lung lavage following injurious ventilation, were treated with Saline, NaHCO₃, or Trometamol. In the hypercapnia, minute ventilation and tidal volume were unchanged during NaHCO₃ administration; however, one hour after the end of NaHCO₃ these parameters decreased (82.1+/−7.8 %, 90.8+/−6.0 % of the baseline, respectively, p < 0.05). Trometamol reduced minute ventilation, tidal volume, and respiratory rate after infusion (59.8+/−19.0 %, 87.0+/−9.2 %, 68.2+/−18.4 % of the baseline, respectively, p < 0.05). Alkaline agents did not cause a large change in the cerebrospinal fluid acid-base balance. In the lung injury model, NaHCO₃ and Trometamol had little effect on ventilation. However, Trometamol reduced transpulmonary pressure. Trometamol exerted more inhibitory effects on ventilation than NaHCO₃ in the hypercapnia model, and Trometamol reduced the transpulmonary pressure in the lung injury model.

本研究旨在研究碱性药物对减少强烈吸气用力的影响。用盐水、NaHCO ₃或氨基丁三醇治疗通过损伤通气后重复肺灌洗诱发的高碳酸血症或肺损伤的兔。在高碳酸血症中，NaHCO ₃给药期间每分钟通气量和潮气量没有变化；然而，NaHCO ₃结束后一小时这些参数降低（分别为基线的 82.1+/-7.8%、90.8+/-6.0%，p < 0.05）。氨基丁三醇降低了输注后的分钟通气量、潮气量和呼吸频率（分别为基线的 59.8+/-19.0%、87.0+/-9.2%、68.2+/-18.4%，p < 0.05）。碱性药物不会引起脑脊液酸碱平衡的大变化。在肺损伤模型中，NaHCO ₃和氨基丁三醇对通气影响不大。然而，氨丁三醇降低了跨肺压。Trometamol在高碳酸血症模型中对通气的抑制作用比 NaHCO ₃更强，在肺损伤模型中 Trometamol 降低跨肺压。