Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiesterase that historically attracted much attention for its involvement in male impotence, in the regulation of vascular smooth muscle cell function. The overall goal is to underscore the importance of PDE5 expression and activity in this cell type in the context of the organs where its function has been extensively studied.

中文翻译：

---

5 型磷酸二酯酶 (PDE5) 和血管树：从胚胎发生到衰老和疾病。

血管树的发育取决于内皮细胞和血管平滑肌细胞的及时分化。后者是形成血管支架的关键参与者，血管支架对血流提供阻力。本综述旨在概述 PDE5，cGMP 特异性磷酸二酯酶，历史上因其参与男性阳痿而备受关注，在调节血管平滑肌细胞功能中的作用。总体目标是强调 PDE5 表达和活性在这种细胞类型中的重要性，在其功能已被广泛研究的器官的背景下。