Abstract Antioxidants are radical scavengers that have been proposed to be involved in many pathological conditions, from aging to degenerative disorders. The aim of the present study is the preparation, structural characterization and antioxidant efficacy evaluation of inclusion complexes (ICs) of two synthetic antioxidants with β-CD. The compounds under study are heterocyclic hybrid molecules, which combine the quinolinone framework and the pyrazoline moiety in one molecular scaffold. The ICs were thoroughly investigated in terms of structure using various techniques such as DLS, NMR, FT-IR, TGA and DSC. The findings revealed a different structural profile between the two ICs. Furthermore, the ICs were examined for their ability to scavenge radicals such as DPPH and 4-hydroxy-TEMPO in ethanol medium. Overall, β-CD could act as a promising host for the synthesized antioxidants as it increases their water solubility without inhibiting their radical scavenging ability.

中文翻译：

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β-环糊精作为新型抗氧化剂的载体：结构和功效研究

摘要 抗氧化剂是自由基清除剂，已被提议参与许多病理状况，从衰老到退行性疾病。本研究的目的是制备两种含 β-CD 的合成抗氧化剂的包合物 (IC) 的制备、结构表征和抗氧化功效评估。所研究的化合物是杂环杂化分子，它在一个分子支架中结合了喹啉酮骨架和吡唑啉部分。使用各种技术，如 DLS、NMR、FT-IR、TGA 和 DSC，对 IC 的结构进行了彻底研究。研究结果揭示了两个 IC 之间的不同结构特征。此外，还检查了 IC 在乙醇介质中清除自由基（如 DPPH 和 4-羟基-TEMPO）的能力。全面的，