Abstract

Artemisia sieversiana is an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1–3) and known compounds from A. sieversiana and investigated their activities. The absolute configuration of 1 was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2 and 3) with similar structures were identified, and their configurations were determined. The trypanocidal activities of the isolated compounds (1–18) against Trypanosoma congolense and the pathogen responsible for fatal trypanosomosis in animals were estimated. Flavonoids and lignans were identified as active compounds with IC₅₀ values ranging from 2.9 to 90.2 µM

Graphic abstract

中文翻译：

---

蒙古采集的蒿蒿中倍半萜，类黄酮和木脂素的锥虫杀虫活性的分离和评估。

摘要

西洋蒿（Artemisia sieversiana）是一年生草本植物，分布在中亚和东亚欧亚大陆，在蒙古被认为是不受欢迎的牧草植物。它会影响牲畜，因此需要有关其化学成分的信息。我们分离出三个新的倍半萜（1 - 3），并从已知的化合物甲。sieversiana并调查了他们的活动。的绝对构型1使用单晶X射线衍射结晶学成立，它的构型从那些具有类似结构的化合物报道的不同。另外两个新的倍半萜（2和3）具有相似的结构，并确定了它们的构型。估计了分离出的化合物（1 – 18）对锥虫锥虫和导致动物致命锥虫病的病原体的锥虫活性。黄酮和木脂素被鉴定为活性化合物，IC ₅₀值在2.9至90.2 µM之间

图形摘要