当前位置: X-MOL 学术Soc. Cogn. Affect. Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effects of HF-rTMS over the left and right DLPFC on proactive and reactive cognitive control
Social Cognitive and Affective Neuroscience ( IF 4.2 ) Pub Date : 2020-07-01 , DOI: 10.1093/scan/nsaa082
Matias M Pulopulos 1 , Jens Allaert 1, 2, 3 , Marie-Anne Vanderhasselt 1, 2, 3 , Alvaro Sanchez-Lopez 4 , Sara De Witte 1, 2, 3 , Chris Baeken 2, 3, 5 , Rudi De Raedt 1
Affiliation  

Abstract
Previous research supports the distinction between proactive and reactive control. Although the dorsolateral prefrontal cortex (DLPFC) has been consistently related to these processes, lateralization of proactive and reactive control is still under debate. We manipulated brain activity to investigate the role of the left and right DLPFC in proactive and reactive cognitive control. Using a single-blind, sham-controlled crossover within-subjects design, 25 young healthy females performed the ‘AX’ Continuous Performance Task after receiving sham vs active high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) to increase left and right DLPFC activity. Reaction times (RTs) and pupillometry were used to assess patterns of proactive and reactive cognitive control and task-related resource allocation, respectively. We observed that, compared to sham, HF-rTMS over the left DLPFC increased proactive control. After right DLPFC HF-rTMS, participants showed slower RTs on AX trials, suggesting more reactive control. However, this latter result was not supported by RTs on BX trials (i.e. the trial that specifically assess reactive control). Pupil measures showed a sustained increase in resource allocation after both active left and right HF-rTMS. Our results with RT data provide evidence on the role of the left DLPFC in proactive control and suggest that the right DLPFC is implicated in reactive control.


中文翻译:

HF-rTMS 在左右 DLPFC 上对主动和被动认知控制的影响

摘要
以前的研究支持主动控制和被动控制之间的区别。尽管背外侧前额叶皮层 (DLPFC) 一直与这些过程相关,但主动和反应控制的侧向化仍在争论中。我们操纵大脑活动来研究左右 DLPFC 在主动和被动认知控制中的作用。使用单盲、假控制的受试者内交叉设计,25 名年轻健康女性在接受假vs后执行“AX”连续性能任务主动高频重复经颅磁刺激 (HF-rTMS) 以增加左右 DLPFC 活动。反应时间 (RTs) 和瞳孔测量分别用于评估主动和被动认知控制的模式以及与任务相关的资源分配。我们观察到,与假手术相比,左侧 DLPFC 上的 HF-rTMS 增加了主动控制。在右 DLPFC HF-rTMS 之后,参与者在 AX 试验中显示出较慢的 RT,表明更多的反应控制。然而,BX 试验(即专门评估反应控制的试验)中的 RT 不支持后一种结果。瞳孔测量显示在活跃的左右 HF-rTMS 后资源分配持续增加。
更新日期:2020-07-01
down
wechat
bug