Current antiretroviral HIV therapies continue to have problems related to procedural complications, toxicity, and uncontrolled side effects. In this study, amino phenylboronic acid-modified carbon dots (APBA-CDs) were introduced as a new nanoparticle-based on gp120 targeting that inhibits HIV-1 entry processes. Prolonged by simple pyrolysis for preparing carbon dots, this report further explores attributing amino phenylboronic acid on carbon dots, which prove the formation of graphene-like structures on carbon dots and boronic acid sites, thereby enabling the enhancement of positive optical properties through photoluminescent detection. Aside from performing well in terms of biocompatibility and low cytotoxicity (the CC₅₀ reach up to 11.2 mg/mL), APBA-CDs exhibited superior capabilities in terms of prohibiting HIV-1 entry onto targeted MOLT-4 cells recognized by the delimitations of syncitia formation and higher ATP signal rather than bare carbon dots. The modified carbon dots also promote dual-action on HIV-1 treatment by both intracellularly and extracellularly viral blocking by combining with the Duviral drug, along with compressing p24 antigen signals that are better than APBA-CDs and Duviral itself.

中文翻译：

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通过与氨基苯硼酸归因于碳点的整体阻断来灭活HIV-1感染。

当前的抗逆转录病毒HIV治疗仍然存在与程序并发症，毒性和无法控制的副作用有关的问题。在这项研究中，氨基苯基硼酸修饰的碳点（APBA-CDs）作为基于gp120靶向的新型纳米颗粒被引入，可抑制HIV-1进入过程。通过简单的热解来制备碳点，本报告进一步探讨了将氨基苯基硼酸归因于碳点，这证明了在碳点和硼酸位点上形成了石墨烯样结构，从而能够通过光致发光检测增强正光学性质。除了在生物相容性和低细胞毒性方面表现出色（CC ₅₀达到最高11.2 mg / mL的浓度），APBA-CD在阻止HIV-1进入目标性MOLT-4细胞方面表现出卓越的能力，而后者被形成的合胞体形成和更高的ATP信号而非裸露的碳点所识别。修饰的碳点还可以通过与Duviral药物结合，通过胞内和胞外病毒阻断，促进对HIV-1治疗的双重作用，同时压缩优于APBA-CD和Duviral本身的p24抗原信号。