Objectives: Our objective was to evaluate the association of weather factors with the risk of pain exacerbations in people with symptomatic hip osteoarthritis (OA).

Method: Eligible participants with symptomatic hip OA were instructed to log on to the study website and complete questionnaires every 10 days and additionally whenever they considered they were experiencing a pain exacerbation (case period) during the 90 day follow-up. Pain exacerbation was defined as an increase of two points in pain intensity on an 11-point numeric rating scale (0–10) during the follow-up compared with baseline. Each case period was anchored to four control periods within a 35 day interval using a time-stratified approach. Weather data were obtained for both periods from the publicly available meteorological database of the Australian Bureau of Meteorology. We examined the association of weather factors across 72 h before the index date with the risk of pain exacerbation, using conditional logistic regression.

Results: Among 252 participants recruited, 129 participants had at least one episode of pain exacerbation and were included in the analysis. A significant dose–response relationship was found between average daily temperature variation in the prior 72 h and risk of pain exacerbations (p = 0.04 for linear trend). There was no significant association between maximum daily temperature, minimum daily temperature, relative humidity, precipitation, or barometric pressure and hip pain exacerbations.

Conclusion: The overall results suggest that only daily temperature variation among different weather factors was associated with hip pain exacerbations in people with symptomatic hip OA.

目的：我们的目的是评估天气因素与有症状的髋骨关节炎（OA）患者疼痛加重的风险之间的关系。

方法：符合条件的有症状髋关节OA的受试者被指示登录研究网站并每10天以及在他们认为他们在90天的随访期间经历疼痛加重（病例期）的情况下填写问卷。疼痛加重定义为在随访过程中，与基线相比，疼痛强度在11点数字评分量表（0-10）上增加了2点。使用时间分层方法，将每个病例期在35天的间隔内固定到四个控制期。这两个时期的天气数据都是从澳大利亚气象局的公共气象数据库中获得的。我们使用条件对数回归分析了索引日期前72小时内天气因素与疼痛加重风险的关系。

结果：在252名受试者中，有129名受试者至少发作了1次疼痛加重，并纳入分析。在之前72小时的平均每日温度变化与疼痛加剧的风险之间发现了显着的剂量反应关系（线性趋势p = 0.04）。最高每日温度，最低每日温度，相对湿度，降水或气压与髋部疼痛恶化之间无显着关联。

结论：总体结果表明，在有症状的髋骨关节炎患者中，只有不同天气因素之间的每日温度变化与髋关节疼痛加重有关。