Millions of people worldwide with incurable liver disease die because of inadequate treatment options and limited availability of donor organs for liver transplantation. Regenerative medicine as an innovative approach to repairing and replacing cells, tissues, and organs is undergoing a major revolution due to the unprecedented need for organs for patients around the world. Induced pluripotent stem cells (iPSCs) have been widely studied in the field of liver regeneration and are considered to be the most promising candidate therapies. This review will conclude the current state of efforts to derive human iPSCs for potential use in the modeling and treatment of liver disease.

中文翻译：

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用于治疗肝病的诱导多能干细胞：新概念

由于治疗选择不足和肝移植供体器官的可用性有限，全世界有数百万患有无法治愈的肝病的人死亡。由于世界各地患者对器官的空前需求，再生医学作为一种修复和替换细胞、组织和器官的创新方法正在经历一场重大革命。诱导性多能干细胞（iPSCs）在肝再生领域得到广泛研究，被认为是最有前途的候选疗法。这篇综述将总结目前为推导出人类 iPSC 以用于肝病建模和治疗的潜在用途所做的努力。