Abstract

The 1,1′-disubstitution is currently the most frequent substitution pattern encountered in the ferrocene series. Here an original access based on the remote deprotometalation of N,N-diisopropyl-2-trimethylsilylferrocenecarboxamide is reported. The key intermediate, 1′-iodo-N,N-diisopropylferrocenecarboxamide, was prepared in multiple grams and was further functionalized toward fifteen 1′-substituted iodoferrocenes.

中文翻译：

---

N，N-二异丙基-2-三甲基甲硅烷基二茂铁羧酰胺的远程去原金属化-碘分解：通往1,1'-二取代二茂铁的新途径

摘要

1，1'-二取代目前是二茂铁系列中最常见的取代方式。这里报道了基于N，N - N-二异丙基-2-三甲基甲硅烷基二茂铁羧酰胺的远程去金属化的原始途径。制备了数克的关键中间体1'-碘-N，N-二异丙基二茂铁羧酰胺，并将其进一步官能化为15个1'-取代的碘代二茂铁。