Doxorubicin, an old chemotherapy drug known as "the red devil" because of its distinctive hue and toxicity, remains a key treatment for many cancer patients. But a new study reports the drug can be tweaked to reduce its most punishing side effect, cardiac damage, without blunting its ability to curb tumors. The work, from a team in the Netherlands, upends conventional thinking about doxorubicin and related drugs, suggesting they do not need to directly damage DNA to kill cancer cells. The Dutch team now plans to test two potentially safer versions of doxorubicin9s drug class in people. But the scientists have found little corporate interest, and one onlooker is skeptical of their plan to develop the drugs on their own.

中文翻译：

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一种五颜六色的化疗剂可以降低毒性

多柔比星是一种古老的化疗药物，因其独特的色调和毒性而被称为“红魔”，仍然是许多癌症患者的关键治疗方法。但是一项新的研究报告称，可以对这种药物进行调整，以减少其最严重的副作用——心脏损伤，而不会削弱其抑制肿瘤的能力。这项来自荷兰团队的工作颠覆了关于阿霉素和相关药物的传统思维，表明它们不需要直接破坏 DNA 来杀死癌细胞。荷兰队现在计划在人中测试两种可能更安全的多柔比星药物类别。但是科学家们几乎没有发现公司的兴趣，一位旁观者对他们自己开发药物的计划持怀疑态度。