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Iridium-Catalyzed Enantioselective Hydrogenation of Indole and Benzofuran Derivatives.
Chemistry - A European Journal ( IF 4.3 ) Pub Date : 2020-07-02 , DOI: 10.1002/chem.202002532
Yao Ge 1, 2 , Zheng Wang 1 , Zhaobin Han 1 , Kuiling Ding 1, 2, 3
Affiliation  

Enantioselective hydrogenation of a broad spectrum of N‐, O‐, and S‐containing aromatic benzoheterocycles or nonaromatic unsaturated heterocycles has been realized by using an Ir/SpinPHOX (SpinPHOX=spiro[4,4]‐1,6‐nonadiene‐based phosphine‐oxazoline) complex as the catalyst, affording an array of the corresponding chiral benzoheterocycles (30 examples) with excellent enantioselectivities (>99 % ee in most cases) and turnover numbers up to 500.

中文翻译:

铱和苯并呋喃衍生物的铱催化对映选择性加氢。

通过使用Ir / SpinPHOX(SpinPHOX = spiro [4,4] -1,6-壬二烯基膦,已经实现了对N,O和S的各种芳族苯并杂环或非芳族不饱和杂环的对映选择性氢化) -恶唑啉)络合物作为催化剂,可提供一系列相应的手性苯并杂环化合物(30个实例),具有出色的对映选择性(大多数情况下> 99%  ee),周转数高达500。
更新日期:2020-07-02
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