Peri‐implant disease is an inflammatory condition affecting the soft and hard tissues surrounding a dental implant. However, current preventative methods are insufficient due to the limited bioactivity on the dental implant and poor patient compliance. Recently, photo‐biomodulation (PBM) therapy that can recover and regenerate peri‐implant soft tissue has attracted considerable attention in dentistry. In this paper, a seamless human oral motion‐powered dental implant system (called Smart Dental Implant or SDI) is presented as an ambulatory PBM therapy modality. SDI allows the in situ light delivery, which is enabled by the energy harvesting from dynamic human oral motions (chewing and brushing) via an engineered piezoelectric dental crown, an associated circuit, and micro light emitting diodes (LEDs). The SDI also offers adequate mechanical strength as the clinical standards. Using primary human gingival keratinocytes (HGKs) as a model host organism and Pseudomonas aeruginosa lipopolysaccharides (LPS) as a model inflammatory stimulus, effective SDI‐mediated PBM therapy is demonstrated. A new class of dental implants could be an ambulatory PBM therapy platform for the prevention of peri‐implant disease without patient dependency, warranting long‐lasting dental implants.

中文翻译：

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用于原位动态光生物调节疗法的人类口腔动力智能牙科植入物（SDI）。

种植体周围疾病是一种炎症性疾病，会影响到牙齿种植体周围的软组织和硬组织。然而，由于牙植入物上的生物活性有限和患者依从性差，当前的预防方法是不足的。最近，可以恢复和再生植入物周围软组织的光生物调节（PBM）治疗在牙科领域引起了相当大的关注。在本文中，提出了一种无缝的人类口腔运动动力式牙种植体系统（称为Smart Dental Implant或SDI）作为动态PBM治疗方法。SDI允许原位光传输，这是通过工程化的压电牙冠，相关电路和微发光二极管（LED）从动态人类口腔运动（咀嚼和刷牙）中收集能量而实现的。SDI还提供了足够的机械强度作为临床标准。使用原代人牙龈角质形成细胞（HGK）作为模型宿主生物铜绿假单胞菌脂多糖（LPS）作为一种模型炎症刺激，已证明有效的SDI介导的PBM治疗。新型的牙科植入物可能是一种动态的PBM治疗平台，用于在没有患者依赖的情况下预防植入物周围疾病，从而保证了持久的牙科植入物。