The genetic mechanisms contributing to lifespan variation remain unresolved. Based on recent conceptual advances in our understanding of epigenetic potential and the relocalization of chromatin modifiers (RCM), we hypothesize that increased CpG density is protective against age-related erosion of the epigenetic landscape and may explain interspecific variation in lifespan.

中文翻译：

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CpG密度是表观遗传衰老与寿命之间的联系吗？

导致寿命变化的遗传机制仍未解决。基于对表观遗传潜能和染色质修饰剂（RCM）的重新定位的最新概念进展，我们推测CpG密度的增加可防止表观遗传景观的年龄相关侵蚀，并可以解释寿命的种间差异。